A line by Lisa, cut from the DVD of IICY?, reveals that every other place they applied to rejected them; Great Prairie can be assumed to be a crap college.
In real life, "Prairie State" is an unofficial nickname for Illinois.
Great Prairie in fanfiction
In the 'D-404' reality of the Daria Multiverse, Great Prairie is located in East Peoria, Illinois, and is the site of Brother Grimace's fic Spirit Stick (which includes Brittany being freed from the clutches of eldridtch, multi-dimensional beings by the Ringbearer Valkryie).
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