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Transpersonal Psycheidetic Seizure Disorder, also called Psycheidetic Epilepsy or Mirror Neuron Epilepsy is a variety of epilepsy characterized by frequent pseudo tonic-clonic seizures originating in the premotor cortex and inferior parietal cortex, areas of the brain thought to contain the neuronal assemblies that give rise to mirror neuron activity in humans. This diagnosis is controversial because the first descriptions of the disease by Kyojio Niide stated that the seizures were caused by the entire consciousness of another person (the co-patient) superimposing itself on the patient. Although Niide rejected any paranormal explanation for the condition, even coining the term psycheidetic to separate it from such associations, his insistence that the neural events of a seizure were disruptions of the patient's consciousness by neural events identical to the co-patient's consciousness caused the diagnosis to be met with skepticism and derision. As the incidence of pseudo tonic-clonic seizures increased, however, Niide's terminology came into general use, even among neurologists who rejected Niide's analysis of neural activity during a seizure. Other neurologists, including many who originally rejected Niide's analysis, have since taken the position that the condition is proof of the existence of Psi abilities in humans.
Niide remains faithful to his original position: Psi abilities do not exist, and any experience of another's consciousness must necessarily result in profound neurological dysfunction (Niide's hypothesis). This has led to further controversies over the prognosis and treament of the condition.
The general prognosis for patients who present with pseudo tonic-clonic seizures in adolescence is quite poor. Less than 5% of patients survive more than two years after the initial diagnosis. Death usually occurs as a consequence of drug resistant convulsive status epilepticus.